Novel steroids

US4396614A · kind A · utility

Assignee

• Roussel Uclaf · FR

Inventors

• Lucien Nedelec · Le Raincy, FR
• Vesperto Torelli · Maisons-Alfort, FR
• Daniel Philibert · Thourotte, FR

Key dates

• Filing date: Dec 21, 1981
• Grant date: Aug 2, 1983
• Expiry date: Dec 21, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J51/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel steroids of the formula ##STR1## wherein R is selected from the group consisting of R.sub.1 and R.sub.2, R.sub.1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms R.sub.2 is --(CH.sub.2).sub.n --R.sub.3, n is an integer from 1 to 8 and R.sub.3 is selected from the group consisting of free or protected --OH, free or protected --NH.sub.2, monoalkyl and dialkylamino with 1 to 6 carbon atoms, a free, esterified or salified --COOH and halogen X and Y together form ##STR2## or X is OH and Y is --CH.sub.2 --CH.sub.2 --COOM, M is selected from the group consisting of hydrogen, an alkali metal and --NH.sub.4, Ra is selected from the group consisting of hydrogen and methyl, the dotted line in the I(2)-position indicates the optional presence of a double bond and the wavy line indicates that R may be in the .alpha.- or .beta.-position, with the proviso that R is not R.sub.1 or R.sub.2 when n is 1 and R.sub.3 is halogen, when the 1(2) bond is a simple bond and when Ra is --CH.sub.3, R.sub.3 is not a free carboxyl when Y is --CH.sub.2 --CH.sub.2 --COOM in which M is an alkali metal or --NH.sub.4 and R.sub.3 is not a salifi…