Preparation of biocompatible materials by immobilization of apyrase
US4396716A · kind A · utility
6Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 28, 1981 |
| Grant date | Aug 2, 1983 |
| Priority date | — |
| Expiry date | Dec 28, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L33/0047
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A prosthetic polymer material is made non-thrombogenic by immobilizing apyrase on its surface. Immobilization is preferably carried out by hydrolytically activating the surface of a polyamide polymer or a polyethylene terphthalate polymer, and treating the hydrolyzed polymer with a solution of cross-linking agent and a solution of apyrase. The apyrase converts adenosine diphosphate to adenosine monophosphate and adenosine whereby the formation of thrombi is inhibited.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.