Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4397854A · kind A · utility
60Cited by
1References
5Claims
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Key dates
| Filing date | Nov 30, 1981 |
| Grant date | Aug 9, 1983 |
| Priority date | — |
| Expiry date | Nov 30, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents. Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted .gamma.-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product. The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.