Polymeric anti-tumor agent and method of preparation
US4397995A · kind A · utility
4Cited by
11References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1980 |
| Grant date | Aug 9, 1983 |
| Priority date | — |
| Expiry date | Dec 29, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved pharmaceutically active derivative of a copolymer of olefin monomer and .alpha.,.beta.-unsaturated polycarboxylic anhydride is prepared by reacting the copolymer with aqueous ammonia, spray drying the resulting aqueous solution of half-amide, half-ammonium salt and thermally imidating the resulting substantially dry, solid particulate product by simultaneous treatment with elevated temperature and removal of water until 5-40% of the derivative half-amide, half-ammonium salt groups are converted to imide groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.