Patent · US Expired

Coumarin derivatives and method for synthesizing 5'-methyl psoralens therefrom

US4398031A · kind A · utility

24Cited by

2References

10Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Dean R. Bender · Hazlet, US
John E. Hearst · Berkeley, US
Henry Rapoport · Berkeley, US

Key dates

Filing date	Mar 9, 1982
Grant date	Aug 9, 1983
Priority date	—
Expiry date	Mar 9, 2002

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D311/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Two species of a coumarin derivative are disclosed, both of which may be produced from a 7-hydroxycoumarin precursor. The one species is an oxime and the other is a .beta.-haloallyl ester. A method for making a psoralen compound in high yield comprises treating these coumarin derivatives with an acid to fuse a furan ring thereto, and recovering a 5'-methyl psoralen therefrom. The 5'-methyl psoralen may be produced in up to about 70% overall yield with respect to the 7-hydroxycoumarin precursor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.