Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl)heptanoates
US4399290A · kind A · utility
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Key dates
| Filing date | Dec 9, 1981 |
| Grant date | Aug 16, 1983 |
| Priority date | — |
| Expiry date | Dec 9, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Optically active tert-alkyl 7-2(oxo-5-carbonyloxypyrrolidinyl)heptanoates and their preparation by reaction of racemic tert-alkyl 7-(2-oxo-5-carboxypyrrolidinyl)heptanoate with an optically active amine to form resolved d or l amine salts which are then reacted with acid to form resolved acid intermediates. Esterification of these acid intermediates produces resolved d or l esters which are useful to make optically active 8-azaprostanoids having biological activity.
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