Antiviral 1-aryl-5-amino-1-penten-3-ones

US4400380A · kind A · utility

Assignee

• Merrell Dow Pharmaceuticals Inc. · US

Inventors

• Harry W. Ritter · Hanau, DE
• Michael L. Edwards · Cincinnati, US

Key dates

• Filing date: Jun 22, 1981
• Grant date: Aug 23, 1983
• Expiry date: Jun 22, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R is H, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, 3,4-methylenedioxy, CF.sub.3, NO.sub.2, NH.sub.2, N(C.sub.1-4 alkyl).sub.2, CN, OH, --S(C.sub.1-4 alkyl) or --SO.sub.2 (C.sub.1-4 alkyl); R.sub.1 and R.sub.2 are independently each H or C.sub.1-4 alkyl or taken together with the attached N atom are morpholino, piperidino, pyrrolidino, piperazino, or N-- C.sub.1-4 -alkyl piperazino; and, when R is halo, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, x is 0-3 and, otherwise, is 0 or 1; PA1 or a pharmaceutically acceptable salt thereof with an acid or for the compounds wherein R.sub.1 and R.sub.2 are both not H, a quaternary ammonium salt thereof with a C.sub.1-4 alkyl halide PA1 have valuable antiviral activity, e.g., for treatment of infections caused by a herpes virus.