Piperazine derivatives of theophylline
US4400381A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 1981 |
| Grant date | Aug 23, 1983 |
| Priority date | — |
| Expiry date | Jul 31, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkylamine, n-lower alkylamine, and aryl piperazino; PA0 Z.sub.1 and Z.sub.2 are each independently selected from the group consisting of CH.sub.2, CHOB and C.dbd.O, wherein B is selected from the group consisting of hydrogen and alkanoyl; PA0 Y is oxygen or sulfur; PA0 n is an integer from 0-4 but cannot be zero when Z.sub.1 is CHOB; PA0 m is an integer from 0-4 but cannot be zero when Z.sub.2 is CHOB, or when m is hydrogen; PA0 R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, halogen, hydroxy, trifluoromethyl, alkyl or alkoxy; and PA0 R.sub.4 and R.sub.5 are each independently lower alkyl, with the proviso that both R.sub.4 and R.sub.5 cannot be methyl when M is hydrogen; are antihistamines and are therefore useful in the treatment of respiratory diseases including asthma, hay fever, allergies and the common cold. They are also vasodilators.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.