Tri-, tetra, and penta-peptides, their preparation and compositions containing them
US4401658A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 17, 1981 |
| Grant date | Aug 30, 1983 |
| Priority date | — |
| Expiry date | Dec 17, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides tri-, tetra- or penta-peptides of the general formula: ##STR1## in which RCO is a fatty acid residue, R.sub.1 is hydroxyl, amino, alkoxy or benzyloxy, R.sub.2 and R.sub.4 (identical or different) represent hydrogen, carboxyl, alkoxycarbonyl or benzyloxycarbonyl or an optionally esterified N-carbonylglycyl or N-carbonyl-D-alanyl radical, it being impossible for R.sub.2 and R.sub.4 simultaneously to represent hydrogen, R.sub.3 is hydrogen, or represents a glycyl or D-alanyl residue (in which case, only one of the radicals R.sub.2 and R.sub.4 can represent an N-carbonylglycyl or N-carbonyl-D-alanyl radical), X is a sulphur atom or methylene, and m and n=1 or 2, it being understood that if X is methylene, m and n are different from 1, their salts, their preparation and compositions containing them: the compounds are useful as vaccine adjuvants or as non-specific stimulants of anti-infectious or anti-tumoral activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.