Cephalosporins

US4401667A · kind A · utility

Assignee

• Karl Thomae GmbH · DE

Inventors

• Bernd Wetzel · Biberach an der Riß, DE
• Eberhard Woitun · Biberach an der Riß, DE
• Wolfgang Reuter
• Roland Maier · Biberach an der Riß, DE
• Uwe Lechner · Biberach an der Riß, DE
• Hanns Goeth · Biberach an der Riß, DE

Key dates

• Filing date: Nov 20, 1981
• Grant date: Aug 30, 1983
• Expiry date: Nov 20, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein A is phenyl, 4-hydroxy-phenyl, 2-thienyl, 3-thienyl or 3,4-dihydroxy-phenyl; PA1 Het is 4H-5,6-dioxo-1,2,4-triazin-3-yl, 4-methyl-5,6-dioxo-1,2,4-triazin-3-yl, 1-vinyl-tetrazol-5-yl, 1-allyl-tetrazol-5-yl or ##STR2## where n is an integer from 1 to 3, inclusive, PA1 R.sub.1 is hydroxyl, amino, dimethylamino, acetylamino, aminocarbonyl, aminocarbonylamino, aminosulfonyl, aminosulfonylamino, methylcarbonyl, methylsulfonylamino, cyano, hydroxysulfonylamino, methylsulfonyl, methylsulfinyl, a carboxylic acid group or a sulfonic acid group, or --(CH.sub.2).sub.n --R.sub.1 may also be alkyl of 2 to 4 carbon atoms or 2,3-dihydroxy-propyl; PA1 R.sub.2 is an unsubstituted or monosubstituted heterocyclic radical selected from the group consisting of 3-pyridyl, 5-pyrimidinyl, 2-thienyl, 2-furylmethyl, 2-thienylmethyl, 2-imidazolylmethyl, 2-thiazolylmethyl, 3-pyridylmethyl or 5-pyrimidinylmethyl, where the substituent is chlorine, methyl, acetylamino, hydroxyl, methylsulfinyl, methylsulfonyl, aminocarbonyl or aminosulfonyl; and PA1 E is hydrogen or a protective group which is easily removable in vitro or in vivo; and, when E is hydrogen, non-toxic, phar…