Oxytocin derivatives
US4402942A · kind A · utility
14Cited by
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14Claims
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Assignee
Inventor
Key dates
| Filing date | Feb 27, 1981 |
| Grant date | Sep 6, 1983 |
| Priority date | — |
| Expiry date | Feb 27, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New oxytocin derivatives having an inhibitory effect on uterine contractions, pharmaceutical compositions containing the oxytocin derivatives, and use of the derivatives in the production of medicines are described. The derivatives are 1-deamino-(2-O-alkyltyrosine)-oxytocin of the formula ##STR1## wherein Mpa is a 3-mercaptopropionyl residue and X is an alkyl group having 2-4 carbon atoms, preferably an ethyl group. Apart from their inhibitory effect on vasopressin and oxytocin induced uterine contractions, the new oxytocin derivatives are capable of inhibiting the spontaneous contraction pattern of the uterus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.