N.sub.1 -Acyl-N.sub.2 -phenyl-diaminopropanols and pharmaceutical compositions thereof and processes for their preparation

US4402981A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Hans Liepmann · Hannover, DE
• Rolf Hueschens · Hannover, DE
• Wolfgang Milkowski
• Horst Zeugner
• Henning Heinemann · Hannover, DE
• Klaus-Ullrich Wolf · Burgdorf, DE
• Insa Hell · Hannover, DE
• Reinhard Hempel · Hannover, DE

Key dates

• Filing date: Mar 16, 1981
• Grant date: Sep 6, 1983
• Expiry date: Mar 16, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D319/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

N.sub.1 -acyl-N.sub.2 -phenyl-1,3-diaminopropan-2-ols are disclosed which possess ulcer-inhibiting activities. Further disclosed are pharmaceutical compositions which are effective in the treatment and prophylaxis of ulcers and which comprise as a pharmacologically active ulcus-inhibiting ingredient N.sub.1 -acyl-N.sub.2 -phenyl-1,3-diaminopropan-2-ols, or a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutically acceptable diluent. Further disclosed are processes for the preparation of the N.sub.1 -acyl-N.sub.2 -phenyl-1,3-diaminopropan-2-ols.