Method of producing a factor-VIII(AHF)-high-concentrate

US4404131A · kind A · utility

Assignee

• Immuno Aktiengesellschaft fur chemisch-medizinische Produkte · AT

Inventors

• Otto Schwarz · Waldshut-Tiengen, DE
• Yendra Linnau · Wien, AT

Key dates

• Filing date: Jul 29, 1981
• Grant date: Sep 13, 1983
• Expiry date: Jul 29, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/831
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In a method of producing a factor-VIII(AHF)-high-concentrate having a specific activity of at least 2.5 units AHF and a fibrinogen content of less than 0.25 mg/mg protein from human or animal plasma, the plasma is subjected to a multi-step fractionation. The fraction purified by these fractionation measures and enriched in factor VIII (AHF) is subjected to a cryoalcohol precipitation and the resulting precipitate is processed into a stable form.