Resolution of .alpha.-pivaloyloxyethyl-(S)-3-(3,4-dihydroxyphenyl)-2-methylalantinate into its .alpha. and .beta. isomers
US4404392A · kind A · utility
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9Claims
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Key dates
| Filing date | Nov 16, 1981 |
| Grant date | Sep 13, 1983 |
| Priority date | — |
| Expiry date | Nov 16, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Resolution of the .alpha. and .beta. isomers of .alpha.-pivaloyloxyethyl-(S)-3-(3,6-dihydroxyphenyl)-2-methylalaninate is accomplished by; (a) forming the (+) hydrogen tartrate salt of the mixture; (b) fractionally crystallizing the .beta.-isomer salt; and (c) recovering the .alpha.-isomer from the mother liquor by treatment with first a base and second a mineral acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.