Novel lipophilic muramyl peptides and processes for their manufacture

US4406890A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Lajos Tarcsay · Weil am Rhein, DE
• Gerhard Baschang · Bettingen, CH
• Albert Hartmann · Grenzach, DE
• Jaroslav Stanek · Arlesheim, CH

Key dates

• Filing date: Jul 16, 1981
• Grant date: Sep 27, 1983
• Expiry date: Jul 16, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/04
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to muramyl peptide compounds, especially of the formula ##STR1## in which R.sub.1 represents, for example, alkyl or phenyl, PA0 R.sub.3 represents, for example, hydrogen or methyl and PA0 R.sub.5 represents, for example, hydrogen or lower alkyl optionally substituted, for example, by hydroxy, mercapto, or methylthio, and in which one of the radicals PA0 A.sub.1 and A.sub.2 represents a group of the formula ##STR2## in which T represents the group of the formula -NH or -O, and PA0 Y represents an alkylene radical optionally interrupted by a radical of the formula -CO-O- or -CO-NH-, and in which PA0 W represents hydrogen and PA0 Z represents a hydroxy-substituted ethyl group, wherein at least one hydroxy group is esterified by a long-chained acyl radical or PA0 W and Z represent hydroxymethyl, wherein hydroxy is esterified by a long-chained acyl radical, and the other of the radicals A.sub.1 and A.sub.2 represents optionally etherified hydroxy or optionally substituted amino. The novel compounds have immunopotentiating properties.