Oxazole and oxadiazole cephalosporins
US4406898A · kind A · utility
14Cited by
4References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1982 |
| Grant date | Sep 27, 1983 |
| Priority date | — |
| Expiry date | Jan 19, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Broad spectrum cephalosporin antibiotics represented by the betaine structure of the formula ##STR1## wherein R is a 5-membered amino-substituted heterocyclic containing oxygen and nitrogen; R' is e.g., hydrogen or C.sub.1 -C.sub.4 alkyl; and bicyclicpyridinium is a thienopyridinium or a furopyridinium group; are prepared by reacting a silylated 3-iodomethyl cephalosporin with a thienopyridine, e.g., thieno[2,3-b]pyridine or a furopyridine. The compounds are potent antibacterials against gram-positive and gram-negative organisms. Pharmaceutical compositions and a method for treating bacterial infections are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.