Anti-ischemic pharmaceutic compositions
US4407801A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 28, 1981 |
| Grant date | Oct 4, 1983 |
| Priority date | — |
| Expiry date | Sep 28, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/495
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject of the invention is a novel pharmaceutical composition, especially having an anti-ischaemic action, containing, in combination, a high dosage (within the range of from 20 to 80 mg) of the dihydrochloride (or another mineral or organic salt) of 1-(2,3,4-trimethoxybenzyl)piperazine and a disintegrating agent, such as mannitol or sodium carboxymethyl starch, that has the effect of liberating the salt of 1-(2,3,4-trimethoxybenzyl)piperazine virtually instantaneously in the organism, this composition being, furthermore, advantageously enclosed in a thin coating film or held together by a binder that is itself readily disintegrated in situ in the organism in such a manner that it makes possible a "flash" action, that is to say a virtually instantaneous action, of the above-mentioned salt in situ. This composition is administered to the patient at a dosage of from 20 to 80 mg/day.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.