Novel phenylacetic acid derivatives

US4407823A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerald Kirsch · Berlin, DE
• Joachim-Friedrich Kapp · Berlin, DE
• Clemens Rufer

Key dates

• Filing date: Nov 5, 1979
• Grant date: Oct 4, 1983
• Expiry date: Nov 5, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenylacetic acid derivatives of the formula ##STR1## wherein n is an integer of 2 to 5; ##STR2## R.sub.1 is hydrogen, halogen, trifluoromethyl, nitro or amino; R.sub.2 and R.sub.3 each independently is hydrogen or lower alkyl; or together form an ethylene group; PA0 X.sub.1 represents two hydrogen atoms or an oxo group; and PA0 Y.sub.1 is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl or carboxyl; and for derivatives wherein Y is carboxyl, salts thereof with physiologically compatible bases, esters thereof from physiologically acceptable alcohols and amides thereof from physiologically acceptable amines have valuable pharmacological activity, e.g., as antiinflammatory agents.