Gonadostatin
US4409139A · kind A · utility
10Cited by
0References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 10, 1981 |
| Grant date | Oct 11, 1983 |
| Priority date | — |
| Expiry date | Aug 10, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially purified substance has been isolated from bovine gonadal secretions which mediates pituitary hormone secretion, using an extraction and purification sequence that includes gel filtration, partition chromatography and HPLC in that order. The substance, designated gonadostatin, is a moderate-size peptide which below a threshold level selectively inhibits LRF-stimulated pituitary secretion of LH and FSH. Above a threshold level, gonadostatin generally stimulates pituitary hormone secretion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.