Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use
US4410507A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 30, 1981 |
| Grant date | Oct 18, 1983 |
| Priority date | — |
| Expiry date | Dec 30, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A colloidal solution of human serum albumin is prepared by mixing an aqueous solution of the latter with a non-ionic surface-active agent and an acid solution of a tin(II) salt, adjusting the pH to 3.5 to 8.0 and heating at a constant temperature between 45.degree. and 100.degree. C. until complete hydrolysis of the tin(II) salt and denaturation of the albumin have taken place; the colloidal solution can also be lyophilized. By treating the solution or the lyophilizate with a .sup.99m Tc-pertechnetate solution, a colloidal preparation is obtained for scintigraphy of the reticuloendothelial system or the lymphatic system. By suitable pH adjustment, the process makes it possible selectively to obtain colloids with a particle size of, for example, 3.0-0.2 or 0.2-0.03 or below 0.03 .mu.m.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.