Substituted thienobenzodiazepinones and salts thereof

US4410527A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Wolfhard Engel
• Gunther Schmidt · Biberach, DE
• Wolfgang Eberlein · Biberach, DE
• Gunter Trummlitz · Warthausen, DE
• Rudolf Hammer · Ingelheim am Rhein, DE
• Piero Del Soldato · Monza, IT

Key dates

• Filing date: Jan 31, 1983
• Grant date: Oct 18, 1983
• Expiry date: Jan 31, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P1/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R is 1-methyl-4-piperididinyl, 4-methyl-1-piperazinyl, or 3 - or 3 -tropanyl, each of which may optionally have another methyl substituent attached to the heterocyclic ring; PA0 R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; PA0 R.sub.2 is hydrogen, halogen or alkyl of 1 to 4 carbon atoms; and PA0 X is oxygen, --NH-- or --N(CH.sub.3)--; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.