N-Substituted aziridine-2-carboxylic acid derivatives and their immuno-stimulation compositions and methods

US4410532A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Elmar Bosies · Weinheim, DE
• Herbert Berger
• Wolfgang Kampe
• Uwe Bicker · Mannheim, DE
• Alfred Grafe · Mörlenbach, DE

Key dates

• Filing date: Dec 28, 1981
• Grant date: Oct 18, 1983
• Expiry date: Dec 28, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy; or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.