Platinum-diamine complexes, a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumor in mice

US4410544A · kind A · utility

Assignee

• Nederlandse Centrale Organisatie Voor Toegepastnatuurwetenschappelijk Onderzoek · NL

Inventors

• Jan Berg · Sarpsborg, NO
• Francois Verbeek · Harmelen, NL
• Eric J. Bluten · Blaricum, NL

Key dates

• Filing date: Jul 27, 1981
• Grant date: Oct 18, 1983
• Expiry date: Jul 27, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel platinum-diamine complexes having the formula: ##STR1## wherein R.sub.1 and R.sub.2 independently of each other may be selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, a cycloalkyl group having from 3-7 carbon atoms in the ring, an aralkyl group, and an aryl group having 1-20 carbon atoms, whereas R.sub.1 and R.sub.2 together may form a cycloalkyl group having 3-7 carbon atoms in the ring and having the formula: ##STR2## wherein N is 2 to 7 and wherein R.sub.3 and R.sub.4 independently of each other are selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, an aryl group or an aralkyl group having 1-20 carbon atoms in the alkyl group and X is an anionic group, providing that when X is either chlorine or malonate, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not each H; when X is chlorine and R.sub.1 and R.sub.2 are each H, R.sub.3 and R.sub.4 are not each methyl; when X is chlorine and R.sub.1 and R.sub.2 are each methyl, R.sub.3 and R.sub.4 are not each H, and when X is chlorine R.sub.1 is hydrogen and R.sub.2 is methyl and R.sub.3 and R.sub.4 are not each hydrogen.