Polysaccharide matrices comprising macromolecular spacer arms for use as adsorbents in affinity chromatography techniques

US4411832A · kind A · utility

Inventors

• Pedro Cuatrecasas · Baltimore, US
• Indu Parikh · Chapel Hill, US

Key dates

• Filing date: Jul 27, 1981
• Grant date: Oct 25, 1983
• Expiry date: Jul 27, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0072
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Polysaccharide matrices, including polyfunctional macromolecular spacer "arms" coupled to the backbones of such matrices in multipoint attachment, are useful as adsorbents in affinity chromatography techniques to "separate" the matrix from the specific liquid being chromatographed. Exemplary preferred polyfunctional macromolecules include [1] poly-L-lysine, [2] the graft copolymer, poly(L-lysyl-DL-alanine), [3] native albumin and [4] denatured albumin.