8'-[(3-Amino-2-hydroxy-propoxy)]-spiro-[cyclopentane-1,2'(1 'H)-(3'H)naphtalen]-4'(3'H)-ones

US4411913A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Trevor Payne · Arlesheim, CH
• Richard Berthold · Binningen, CH

Key dates

• Filing date: Mar 5, 1979
• Grant date: Oct 25, 1983
• Expiry date: Mar 5, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C45/71
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## wherein (i) m is O, n is 2 and p is 1 or PA0 (ii) m is 0 or 1, n is 1, and p is 1 or PA0 (iii) m is 1, n is 1 or 2 and p is 0, PA0 R.sub.1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl or phenylthioalkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phenyl ring is separated by at least 2 carbon atoms from the nitrogen atom to which R.sub.1 is bound and wherein the phenyl ring is unsubstituted, or mono-substituted by, or independently disubstituted by, alkyl or alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35, trifluoromethyl or cyano, PA0 R.sub.2 and R.sub.3 are either together straight chain alkylene of 4 to 6 carbon atoms, or, independently, hydrogen or alkyl of 1 to 4 carbon atoms, with the proviso that when m is 1, n is 1 and p is 0 then at least one of R.sub.2 and R.sub.3 is other than hydrogen, and PA0 R.sub.4 and R.sub.5 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, are useful in the treatment of coronary disorders.