Process for the preparation of quinolin-4-ones
US4412075A · kind A · utility
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10Claims
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Key dates
| Filing date | Jan 15, 1982 |
| Grant date | Oct 25, 1983 |
| Priority date | — |
| Expiry date | Jan 15, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/233
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1,2,3,4-Tetrahydroquinolin-4-ones of the formula: ##STR1## wherein R represents a hydrogen or halogen atom, an alkyl radical (1 to 4 carbon atoms), an alkoxy radical (1 to 4 carbon atoms) or the trifluoromethyl radical, and R.sub.1 represents a hydrogen atom, an alkyl radical (1 to 4 carbon atoms) or the trifluoromethyl radical, are prepared by cyclizing a 3-anilinopropionic acid of the formula: ##STR2## (wherein R and R.sub.1 are as hereinbefore defined) in a mixture of hydrofluoric acid and boron trifluoride. The quinolinone products are useful intermediates in the synthesis of therapeutically active substances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.