Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles
US4413127A · kind A · utility
7Cited by
4References
6Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 24, 1982 |
| Grant date | Nov 1, 1983 |
| Priority date | — |
| Expiry date | May 24, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/85
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention resides in a process for preparing cardiotonically active 1,2-dihydro-6-(lower-alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles (III) which comprises reacting a pyridinylmethyl lower-alkyl ketone (I) with tri-(lower-alkyl) orthoformate, acetic anhydride and acetic acid to produce 2-(lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketone (II) and then reacting II with malononitrile in a lower-alkanol, where pyridinyl is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.