5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonines

US4415495A · kind A · utility

Assignee

• Godecke Aktiengesellschaft · DE

Inventors

• Gerhard Satzinger · Denzlingen, DE
• Manfred Herrmann
• Edgar Fritschi · Giengen an der Brenz, DE
• Heinrich Bahrmann · Kirchzarten, DE
• Volker Ganser · Glückstadt, DE
• Bernd Wagner · Denzlingen, DE
• Wolfgang Steinbrecher · Gundelfingen, DE

Key dates

• Filing date: Feb 24, 1981
• Grant date: Nov 15, 1983
• Expiry date: Feb 24, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides 5,6;8,9-tetrahydro-7H-dibenz(d,f)azonine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are hydrogen or halogen atoms or lower alkyl or alkoxy radicals, R.sup.3 is a hydrogen atom or a lower alkyl radical, R.sup.4 is a hydrogen atom or a lower alkyl or alkanoyl radical and n is 1 or 2; and the pharmaceutically acceptable salts thereof formed with inorganic and organic acids; but excluding 6-benzyl-2,12-dimethoxy-1-hydroxy-7-methyl-5,6;8,9-tetrahydro-7H-dibenz(d, f)azonine in which case R.sup.1, R.sup.2 and R.sup.4 are hydrogen, n is 1 and R.sup.3 is methyl. The lower alkyl, alkanoyl and alkoxy radicals are straight chained or branched radicals containing 1 to 5 carbon atoms. The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them.