Bis-sparteine derivatives and method of using same in therapy

US4415577A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Bernd Hachmeister · Hannover, DE
• Wolfgang Kehrbach · Hannover, DE
• Ulrich Kuehl · Hannover, DE
• Gerd Buschmann · Velbert, DE

Key dates

• Filing date: Aug 19, 1981
• Grant date: Nov 15, 1983
• Expiry date: Aug 19, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are a novel dimeric sparteine derivative, the 17S,17'S-bissparteine, and its physiologically compatible acid addition salts. Said compounds are produced by dimerization of 17-hydroxy sparteine or 17-dehydrosparteine salts by means of activated magnesium or an alkali metal. Pharmaceutical compositions containing said novel dimeric sparteine derivatives and their preparation are also described.