Use of aminoalkyl phenyl sulfide derivatives for the treatment of hypertension
US4415591A · kind A · utility
3Cited by
10References
8Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 4, 1981 |
| Grant date | Nov 15, 1983 |
| Priority date | — |
| Expiry date | Jun 4, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Hypertension in mammals can be treated by administering an effective amount of an aminoalkyl phenyl sulfide having the formula ##STR1## wherein (C.sub.n H.sub.2n)=a linear or branched alkyl chain of 10 carbons or less (n=1-10); PA1 R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5,=H, OH, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, F, Cl, Br, or I; PA1 R.sub.6 R.sub.7 =H, C.sub.1 -C.sub.4 -alkyl; and the pharmaceutically acceptable salts thereof. The hypotensive potential of the compounds may be evaluated by oxygenation with dopamine-beta-hydroxylase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.