Process for preparation of an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid
US4415657A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 8, 1981 |
| Grant date | Nov 15, 1983 |
| Priority date | — |
| Expiry date | Dec 8, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/939
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process is disclosed in which an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is prepared by subjecting a dialkyl ester of .beta.-protected aminoglutaric acid to the action of a culture broth, cells, or treated cells of a microorganism capable of stereoselectively hydrolyzing only one of the ester groups in the above-mentioned dialkyl ester to produce an optically active monoalkyl ester of .beta.-protected (S)-aminoglutaric acid, and then removing the amino-protecting group from the product. An optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is useful as a starting material for synthesizing .beta.-lactam antibiotics of carbapenem type such as thienamycin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.