Ester of 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanic acid, and its use as antibacterial agent
US4416891A · kind A · utility
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3References
2Claims
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Key dates
| Filing date | Jul 16, 1982 |
| Grant date | Nov 22, 1983 |
| Priority date | — |
| Expiry date | Jul 16, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/40
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
(5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate of the following formula (I) ##STR1## or its pharmaceutically acceptable acid addition salt. The compound is useful as an antibacterial agent and may be prepared by reacting (5-methyl-2-oxo-1,3-dioxolen-4-yl)-methyl 6-aminopenicillanate of the following formula (II) ##STR2## or its acid addition salt with chloro-N,N-hexamethyleneformiminium chloride, and as required, converting the resulting compound to its pharmaceutically acceptable acid addition salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.