Patent · US Expired

Methods of producing HBsAg

US4416986A · kind A · utility

24Cited by

3References

7Claims

0Family size

Assignee

MERCK & CO., INC. · US

Inventors

Henry Z. Markus · Wyncote, US
William J. McAleer · Ambler, US

Key dates

Filing date	Jan 16, 1981
Grant date	Nov 22, 1983
Priority date	—
Expiry date	Jan 16, 2001

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2730/10122
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Hepatitis B surface antigen (HBsAg) is produced in vitro in high titer and purity from tissue cultures of cells that shed HBsAg. The cells are grown on hollow fiber capillary units having a molecular weight cut-off of about 10,000.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.