Process for the preparation of 8.alpha.-substituted 6-methylergolines
US4417051A · kind A · utility
6Cited by
3References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 12, 1981 |
| Grant date | Nov 22, 1983 |
| Priority date | — |
| Expiry date | May 12, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D457/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing an 8.alpha.-substituted 6-methyl-10.alpha.-H-ergoline of the formula ##STR1## wherein R.sub.1 is HN--CO--NX.sub.2 (wherein X is hydrogen, methyl or ethyl), CO--NH--NX.sub.2, CO--NX.sub.2, or CH.sub.2 OX, comprises reducing the corresponding 8.alpha.-substituted-9,10-didehydro-6-methylergoline, with an alkali metal or alkaline earth metal dissolved in a nitrogen compound which is a primary or secondary C.sub.1-3 -alkylamine, a hexa-C.sub.1-2 -alkyl-phosphoric triamide or ammonia at a temperature of -70.degree. to -30.degree. C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.