Process for the preparation of isosorbide 2-nitrate
US4417065A · kind A · utility
1Cited by
2References
9Claims
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Inventor
Key dates
| Filing date | May 24, 1982 |
| Grant date | Nov 22, 1983 |
| Priority date | — |
| Expiry date | May 24, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of isosorbide-2-nitrate of the formula ##STR1## comprising contacting isosorbide with a carboxylic acid anhydride in the presence of a metal salt; esterifying the resultant isosorbide-5-acylate with nitric acid; and converting the resultant isosorbide-5-acylate-2-nitrate to isosorbide-2-nitrate by treatment with an alkyl alcohol in the presence of an alkali metal alcoholate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.