Pyranoquinolinones and analogs thereof

US4419352A · kind A · utility

Assignee

• Fisons Ltd. · GB

Inventors

• David Cox
• Hugh Cairns · Warren, US
• Nigel Chadwick · Moretonhampstead, GB
• John L. Suschitzky · Loughborough, GB

Key dates

• Filing date: Feb 20, 1981
• Grant date: Dec 6, 1983
• Expiry date: Feb 20, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--, PA1 R.sub.4, R.sub.9 and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, --NO.sub.2, --NR.sub.1 R.sub.2, --OR.sub.3, --S(O).sub.n R.sub.3 ; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen, PA1 n is 0, 1 or 2, PA1 R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, alkyl, --CONHR.sub.3, phenyl or phenyl substituted by alkyl or halogen, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring, PA1 R.sub.3 represents hydrogen, alkyl, alkenyl or phenyl, PA1 one of G.sub.1 and G.sub.2 is hydrogen and the other is a group E, PA1 each E, which may be the same or different, is --COOH, a 5-tetrazolyl group, or a carboxamidotetrazole group, PA1 each Z, which may be the same or different, is oxygen or sulphur, and PA1 one or two of the atoms, a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R.sup.9 havin…