Novel supports carrying side chains, processes for obtaining these supports, process for attaching organic compounds having carbohydrate residues one said supports, products and reagents resulting from said chemical fixation

US4419444A · kind A · utility

Assignee

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventor

• Gerard Quash · Craponne, FR

Key dates

• Filing date: Sep 30, 1980
• Grant date: Dec 6, 1983
• Expiry date: Sep 30, 2000

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/816
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Process for chemically binding organic compounds containing carbohydrate residues, onto a support bearing at least one reactive --NH.sub.2, in which at least one --CH.sub.2 OH group of the carbohydrate residue is transformed in a --CHO group, by oxidation and then the --CHO groups thus obtained are reacted with at least a reactive --NH.sub.2 carried by the side chains covalently bound on a solid, insoluble support, the side chains are chosen from among amines, polyamines, diacids, amino-acids, hydrazines, and are eventually coupled, by the intermediary of their reactive --NH.sub.2, with a nitrogen-containing compound chosen from aliphatic or aromatic amines, aliphatic or aromatic hydrazines, or amino acids, comprising eventually jointly a --SH group and a --NH.sub.2 group. Products resulting from this process and biological reagents containing said products as their active constituents.