Hexitols containing free carboxy groups and a process for the preparation thereof
US4419522A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 26, 1981 |
| Grant date | Dec 6, 1983 |
| Priority date | — |
| Expiry date | Oct 26, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new hexitols having the general formula (I) and (II), ##STR1## wherein the hexitol skeleton is dulcitol, mannitol or iditol, PA1 X represents halogen, preferably bromine, PA1 R is a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, and PA1 R.sup.1 is hydrogen, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, a saturated or unsaturated C.sub.2-10 alkylcarbonyl group, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains an alkoxycarbonyl group, or a saturated or unsaturated C.sub.8-10 aralkylcarbonyl group, and salts of these compounds. The new compounds according to the invention have tumor-inhibiting affects. The above compounds are prepared according to the invention so that PA1 (a) a compound of the general formula (IX), wherein PA2 the hexitol skeleton is dulcitol, mannitol or iditol, PA2 Q is a saturated or unsaturated C.sub.11-17 alkylcarbonyl group which also contains a benzyloxycarbonyl group, and PA2 Q.sup.1 is hydrogen, a saturated or unsaturated C.sub.2-10 alkylcarbonyl group, a saturated or unsaturated C.sub.4-10 alkylcarbon…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.