New peptides and a process for their preparation

US4420424A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rolf Geiger · Frankfurt am Main, DE
• Wolfgang Konig · Hofheim, DE
• Gerd Johnscher · Kelkheim, DE

Key dates

• Filing date: Nov 9, 1981
• Grant date: Dec 13, 1983
• Expiry date: Nov 9, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

What are disclosed are pentapeptides, useful for influencing the maturing of T-lymphocytes, of the formula EQU G--K--Q--X--M wherein PA1 G is arginine, lysine, ornithine, or homoarginine, or is an unsubstituted or substituted .omega.-aminoalkanoyl, .omega.-guanidinoalkanoyl, or .omega.-dimethylaminoalkanoyl; PA1 K is a basic amino acid such as lysine, arginine, homoarginine, or ornithine; PA1 Q is L- or D-glutamic acid, d-aspartic acid, or D-.alpha.-aminoadipic acid; PA1 X is L-valine or L-isoleucine; and PA1 M is an L- or D-aminoacid having a hydrophobic side chain, or an ester or amide of such an acid.