Process for the preparation of 4-amino-chloroquinolines
US4421920A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 15, 1982 |
| Grant date | Dec 20, 1983 |
| Priority date | — |
| Expiry date | Jan 15, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
4-Amino-chloroquinolines of the formula: ##STR1## in which R.sub.1 represents a hydrogen atom or an alkyl radical (1 to 5 carbon atoms), and R.sub.2 represents an alkyl radical (1 to 5 carbon atoms) optionally substituted by a dialkylamino group, or a phenyl radical optionally substituted by one or more carboxy and hydroxy radicals and alkyl radicals (1 to 4 carbon atoms) optionally substituted by a dialkylamino group, are prepared by the condensation of an amine of the formula: ##STR2## with a chloro-1,2,3,4-tetrahydroquinolin-4-one of the formula: ##STR3## with aromatization of the tetrahydroquinoline, the reaction being carried out in the presence of a ruthenium based catalyst on a support. The 4-amino-chloroquinoline products are useful as pharmaceuticals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.