Disaggregated solutions of polypeptides, their preparation and use
US4423039A · kind A · utility
3Cited by
6References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 16, 1981 |
| Grant date | Dec 27, 1983 |
| Priority date | — |
| Expiry date | Apr 16, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a solution of a polypeptide, such as, for example, insulin, the solution being prepared and maintained at pH 6.8 to 8.0 and in which the polypeptide remains in solution in disaggregated form. This is accomplished by the use of the bicarbonate ion in the solution, the bicarbonate ion being present in a concentration of 2 mmolar to 2.5 molar. A method for preparing the polypeptide solution and the use of the solution in maintaining normoglycemia are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.