3-Vinylcephalosporin derivatives
US4423214A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 19, 1981 |
| Grant date | Dec 27, 1983 |
| Priority date | — |
| Expiry date | Nov 19, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New 3-vinylcephalosporin derivatives of the general formula: ##STR1## in the form of a bicyclooct-2-ene or bicyclooct-3-ene, in which formula R.sub.5.sup.a and R.sub.5.sup.b are hydrogen atoms or alkyl radicals, or together form an alkyl radical containing 2 or 3 carbon atoms, R.sub.5.sup.c is an acid-protecting radical, R.sub.1 is an amino-protecting radical, R.sub.2 is an acid-protecting radical or a radical which can be removed by an enzymatic method, and R.sub.3 and R.sub.4, which are identical or different, represent alkyl (optionally substituted by hydroxyl, alkoxy, amino, alkylamino or dialkylamino) or phenyl, or together form, with the nitrogen atom, a saturated heterocyclic ring of 5 or 6 members, optionally containing another hetero-atom, their E and Z forms, and their syn and anti forms, and mixtures thereof, and also their preparation. These new compounds are useful as intermediates for the preparation of biologically active cephalosporins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.