Process for the preparation of reactive, couplable derivatives of the thyroid hormones

US4423227A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Hans-Georg Batz · Tutzing, DE
• Winfried Albert · Eberfing, DE
• Helmut Lenz · Tutzing, DE
• Hans-Ralf Linke · Raisting, DE
• Fritz Stahler

Key dates

• Filing date: Sep 30, 1981
• Grant date: Dec 27, 1983
• Expiry date: Sep 30, 2001

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/78
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T.sub.3) and 3,3',5,5'-tetraiodothyronine (T.sub.4) by reaction with reactive carboxylic acid derivatives, which process comprises sylylating all the functional groups of the thyroid hormone by reaction with a reactive triorganosylyl derivative and then reacting the persylylated derivative of the thyroid hormone thus obtained with an activated carboxylic acid derivative.