Thienobenzodiazepinones, pharmaceutical compositions thereof and method of use thereof

US4424225A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Gu/ nther Schmidt · Biberach, DE
• Wolfgang Eberlein · Biberach, DE
• Wolfhard Engel
• Gu/ nter Trummlitz · Warthausen, DE
• Rudolf Hammer · Ingelheim am Rhein, DE
• Piero Del Soldato · Monza, IT

Key dates

• Filing date: Jan 31, 1983
• Grant date: Jan 3, 1984
• Expiry date: Jan 31, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P1/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms; PA0 R.sub.2 is halogen, hydrogen, or alkyl having from 1 to 4 carbon atoms; and PA0 R is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl, 1-methyl-1,2,5,6-tetrahydro-4-pyridinyl, (1-methyl-4-piperidinylidene)-methyl, or (8-methyl-8-azabicyclo3.2.1!oct-3-yl)-methyl, each of which can optionally have an additional methyl substituent on the heterocyclic ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.