Methods of manufacture of nitrile-containing glucuronic acid conjugates
US4424348A · kind A · utility
8Cited by
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4Claims
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Key dates
| Filing date | Oct 13, 1978 |
| Grant date | Jan 3, 1984 |
| Priority date | — |
| Expiry date | Oct 13, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mandelonitrile-.beta.-D-glucuronic acid is produced by condensing a mandelic amide with a tri-O-acetyl methyl ester of glucuronic acid and then reacting the product with acetic anhydride to produce the tri-O-acetyl methyl ester of mandelonitrile-.beta.-D-glucuronic acid. The protecting acetyl groups may be removed and the barium salt formed by reacting with barium hydroxide, which salt, when treated with sulfuric acid, will yield the mandelonitrile-.beta.-D-glucuronic acid. This compound, as well as methacrylonitrile .beta.-D-glucuronic acid may be used in the treatment of bacterial infections having .beta.-glucuronidase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.