Cephem and cepham compounds

US4425340A · kind A · utility

Assignee

• Fujisawa Pharmaceutical Co., Ltd. · JP

Inventors

• Tsutomu Teraji · Osaka, JP
• Kazuo Sakane · Kawanishi, JP
• Jiro Goto

Key dates

• Filing date: Oct 22, 1981
• Grant date: Jan 10, 1984
• Expiry date: Oct 22, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/21
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new cephem and cepham compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino, PA1 R.sup.2 is hydrogen, acyl, aryl which may be substituted with suitable substituent(s), lower alkyl substituted with suitable substituent(s), lower alkenyl, lower alkynyl, cycloalkyl which may be substituted with suitable substituent(s), cyclo(lower)alkenyl, or S or O containing 5-membered heterocyclic group substituted with oxo group(s), PA1 R.sup.3 is hydrogen or lower alkyl, PA1 R.sup.4 is hydrogen, acyloxy(lower)alkyl; acylthio(lower) alkyl; pyridinium(lower)alkyl which may be substituted with suitable substituent(s); a heterocyclicthio(lower)alkyl which may be substituted with suitable substituent(s); lower alkyl;l halogen; hydroxy; thiazolium(lower)alkyl which may be substituted with suitable substituent(s); or lower alkoxy; R.sup.5 is carboxy or a protected carboxy, wherein R.sup.5 is COO.sup.- when R.sup.4 is pyridinium(lower)alkyl which may be substituted with suitable substituent(s) or thiazolium(lower)alkyl which may be substituted with suitable substituent(s), and the heavy solid line means single or double b…