Sulfur-containing isoquinoline derivatives in pharmaceutical compositions and methods of use
US4425349A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 25, 1982 |
| Grant date | Jan 10, 1984 |
| Priority date | — |
| Expiry date | May 25, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns new sulfur-containing isoquinoline derivatives. More particularly, the invention relates to isoquinoline derivatives of the general formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms, PA1 R.sup.1 is hydrogen, alkyl having 1 to 4 carbon atoms and optionally substituted with phenyl, phenyl optionally substituted with one or more halogen or alkoxy group, cyano or carbamoyl, PA1 R.sup.2 is phenyl optionally substituted with one or more halogen, alkoxy or carboxyl, or a group of the general formula A ##STR2## wherein R.sup.3 is hydrogen, a straight or branched chained alkyl having 1 to 4 carbon atoms or phenyl, PA1 m and n independently represent 0, 1 or 2, with the proviso that m+n is at least 1, PA1 R.sup.4 is hydrogen, phenyl, hydroxyl, acyloxy, carboxyl, alkoxycarbonyl having 1 to 6 carbon atoms, carbamoyl, carbazoyl or dialkylamino containing 1 to 6 carbon atoms in the alkyl moiety, or PA1 R.sup.2 is a straight or branched chained alkylene group having 1 to 6 carbon atoms, and PA1 the dotted line stands for a further carbon-carbon bond or hydrogen atoms in the 3- and 4-positions of the ring, PA1 and…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.