Substituted phenyl piperidines

US4426386A · kind A · utility

Assignee

• Astra Lakemedel Aktiebolag · SE

Inventors

• Folke L. Arvidsson · Uppsala, SE
• Per A. E. Carlsson · Göteborg, SE
• Uli A. Hacksell · Uppsala, SE
• John S. M. Hjorth · Göteborg, SE
• Per. L. Lindberg · Mölndal, SE
• John L. G. Nilsson · Tullinge, SE
• Domingo Sanchez · Floda, SE
• Nils U. E. Svensson · Brunna, SE
• Hakan V. Wikstrom · Mölndal, SE

Key dates

• Filing date: Dec 5, 1980
• Grant date: Jan 17, 1984
• Expiry date: Dec 5, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein n is 1 or 2, Y is OH, R.sup.1 COO--, R.sup.2 R.sup.3 NCOO-- or R.sup.4 O whereby R.sup.1 is an alkyl group, or a possibly substituted phenyl group, R.sup.2 is an alkyl, phenethyl, benzyl or phenyl group, R.sup.3 is H or an alkyl group and R.sup.4 is an allyl or benzyl group, and R is an alkyl, hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group or alkenyl group, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.