1,2-Dihydroquinolines connected via an oxyalkyl group with a piperidine ring and having anti-allergic action

US4427680A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Walter-Gunar Friebe · Mannheim, DE
• Werner Winter · Aachen, DE
• Max Thiel
• Androniki Roesch · Mannheim, DE
• Otto-Henning Wilhelms · Weinheim, DE

Key dates

• Filing date: Feb 8, 1982
• Grant date: Jan 24, 1984
• Expiry date: Feb 8, 2002

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides aryl ether derivatives of the general formula: ##STR1## wherein A is an oxygen atom or the group >N--R.sub.1, R.sub.1 being a hydrogen atom or a lower alkyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.4 is a hydrogen atom or a hydroxyl group, R.sub.5 is a hydrogen atom or an acyl radical, R.sub.7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R.sub.8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof. The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.