Cycloalkylamino derivatives and their use in the treatment of peptic ulcers and the like
US4427685A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 3, 1982 |
| Grant date | Jan 24, 1984 |
| Priority date | — |
| Expiry date | Feb 3, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: a is 1 to 3; PA0 b is 0 to 2; PA0 c is 2 to 4; PA0 d is 1 to 5; PA0 X is sulphur, oxygen or --CH.sub.2 --; PA0 Y is oxygen, sulphur, NR.sub.4 or CHR.sub.5 wherein R.sub.4 is hydrogen, C.sub.1-4 alkyl, NO.sub.2 or CN, C.sub.1-4 alkylsulphonyl or phenylsulphonyl optionally substituted in the phenyl moiety by one or two substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, fluorine, chlorine or bromine, and R.sub.5 is NO.sub.2, C.sub.1-4 alkylsulphonyl or optionally substituted phenylsulphonyl as defined for R.sub.4 ; PA0 R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-4 alkyl, or C.sub.3-6 cycloalkyl; or R.sub.1 and R.sub.2 taken together with the nitrogen to which they are attached represent a pyrrolidino or piperidino ring; PA0 R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1-6 alkyl; and PA0 Ar is furan or thiophene attached at positions 2- and 5- or benzene attached at positions 1- and 3- or 1- and 4-, having useful pharmacological activity, processes for their preparation and their use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.